Degeneration and Regeneration in Peripheral Nerves

Description

Degeneration and regeneration in peripheral nerves occur after injury. Wallerian degeneration affects the distal axon segment, where the axon and myelin sheath break down. Schwann cells clear debris and form regeneration tubes. The proximal axon may sprout new growths that follow these tubes toward the target. Successful regeneration depends on the type and extent of injury. Regrowth occurs at about 1–3 mm/day. Unlike the central nervous system, peripheral nerves have a greater capacity for repair due to supportive Schwann cells.