Hematopoetic stem cell transplant

Created by

Muthalagu Ramanathan MD (Oncology), Associate Professor

Dr. Muthalagu Ramanathan MD (Oncology), Associate Professor

Overview

Description

Hematopoietic stem cell transplant (HSCT) is a therapeutic procedure used to treat various hematologic malignancies, bone marrow failure syndromes, and some genetic or autoimmune disorders. It involves infusion of stem cells—either autologous (self) or allogeneic (donor)—to restore bone marrow function after high-dose chemotherapy or radiation. HSCT allows for hematopoietic and immune system reconstitution. Major risks include graft-versus-host disease, infections, and organ toxicity. Careful donor selection, pre-transplant conditioning, and post-transplant monitoring are essential for successful outcomes and long-term survival.

Author

Author image

Dr. Muthalagu Ramanathan MD (Oncology), Associate Professor

Director - Myelodysplastic Syndrome Program, Medical Co-Director - Blood & Marrow Transplant Program.

Director, Myelodysplastic Syndrome Program, Medical Co-Director, Blood & Marrow Transplant Program, University of Massachusetts Medical School, UMass Memorial Medical Center, USA