Sepsis Update

Description

Recent sepsis updates emphasize early recognition using Sepsis-3 criteria, prioritizing organ dysfunction over SIRS. Management focuses on rapid initiation of broad-spectrum antibiotics, 30 mL/kg crystalloid resuscitation, and norepinephrine as first-line vasopressor. Dynamic fluid assessment and lactate-guided therapy optimize resuscitation. Early source control and de-escalation of antimicrobials reduce resistance. Adjunctive strategies include individualized ventilation, corticosteroids for refractory shock, and conservative fluid balance. Sepsis bundles with hour-1 and 3-hour goals improve survival, while telemonitoring and AI-assisted alerts enhance timely interventions.